TA Instruments – RS-DSC
The TA Instruments RS-DSC (Rapid Screening Differential Scanning Calorimeter) is an advanced thermal analysis instrument designed for high-throughput thermal stability testing in biologic drug development. It offers precise and efficient measurement of biomolecule stability, enabling researchers to ensure product quality and accelerate development timelines. Tailored for high-concentration biologic formulations, it addresses the specific needs of antibody drugs and engineered proteins.
Technical Specifications
| TA Instruments RS-DSC | |
| Cell Geometry | Disposable microfluidic |
| Cell Material | Glass |
| Sample Format | MFC (Micro Fluidic Chips) |
| Working cell volume | 11 µL |
| Sample Capacity | 24 MFCs |
| Typical Sample Concentration | 20 mg/mL – 330+ mg/mL IgG (protein dependent)1 |
| Sample throughput | > 96 samples/day |
| Temperature Range | 20-100 °C |
| Temperature Scan Rate | 1 or 2 °C/min |
| Temperature accuracy | ± 0.2 °C (across all calorimeters); ± 0.1 °C reproducibility2 |
| 1Using lysozyme in 0.1 M glycine buffer at pH 2.5 or IgG in PBS at pH 7.4 at 1 °C/min 2 Using DPPC in water at pH 7 at 1 °C/min |
